Adjusting for multiple testing in studies is less important than other concerns
نویسندگان
چکیده
منابع مشابه
Multiple hypothesis testing, adjusting for latent variables
In high throughput settings we inspect a great many candidate variables (e.g. genes) searching for associations with a primary variable (e.g. a phenotype). High throughput hypothesis testing can be made difficult by the presence of systemic effects and other latent variables. It is well known that those variables alter the level of tests and induce correlations between tests. It is less well kn...
متن کاملFetal Vegf Genotype is More Important for Abortion Risk than Mother Genotype
Background VEGF gene has been reported to be related with many diseases and recurrent pregnancy loss in various studies. VEGF polymorphisms are risk factors for pregnancy losses, and generally studies report only women’s genetic analyses. To evaluate the association between VEGF A C405G, C460T, C936T and C2578A polymorphisms and spontaneous abortion, we studied the genotypes of spontaneously a...
متن کاملFor survival, the emergence of oligoclonal bands after multiple myeloma treatment is less important than achieving complete remission
BACKGROUND The emergence of oligoclonal bands, proteins differing from those originally identified at diagnosis, has been reported in multiple myeloma patients after high-dose chemotherapy followed by autologous stem cell transplantation and after successful conventional chemotherapy. The clinical relevance of oligoclonal bands remains unclear, but their emergence has been associated with bette...
متن کاملAdjusting for Multiple Testing in Decision Tree Pruning
Over tting is a widely observed pathology of induction algorithms. Over tted models contain unnecessary structure that re ects nothing more than chance variations in the particular data sample used to construct the model. Portions of these models are literally wrong, and can mislead users. Over tted models require more storage space and take longer to execute than their correctlysized counterpa...
متن کاملDesmoglein 2 Is Less Important than Desmoglein 3 for Keratinocyte Cohesion
Desmosomes provide intercellular adhesive strength required for integrity of epithelial and some non-epithelial tissues. Within the epidermis, the cadherin-type adhesion molecules desmoglein (Dsg) 1-4 and desmocollin (Dsc) 1-3 build the adhesive core of desmosomes. In keratinocytes, several isoforms of these proteins are co-expressed. However, the contribution of specific isoforms to overall ce...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMJ
سال: 1999
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.318.7193.1288a